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. 2009 Dec 28;120(1):303–314. doi: 10.1172/JCI40364

Figure 3. Local vascular Rantes production regulates early CD3+ T cell and CD115+ macrophage infiltration and late neointimal formation following arterial injury.

Figure 3

(A) WT to WT and WT to Rantes–/– mice underwent arterial injury, and cell infiltration was assessed at 1 day. Relative CD3+ T cell infiltration was reduced in WT to Rantes–/– mice compared with WT to WT mice (n = 6 for WT to WT, n = 9 for WT to Rantes–/–; ****P < 0.0005). (B) Relative CD115+ macrophage infiltration was reduced 1 day after arterial injury in WT to Rantes–/– mice compared with WT to WT mice (n = 7 for WT to WT, n = 9 for WT to Rantes–/–; ****P < 0.0005). (C) Neointimal formation at 3 weeks after arterial injury, as assessed by intima/media ratio, was decreased in femoral vessels from WT to Rantes–/– as compared with WT to WT mice (n = 9 for WT to WT, n = 8 for WT to Rantes–/–; **P < 0.001). Data are shown as mean + SEM. (D) Representative cross sections of femoral arteries from WT to WT and WT to Rantes mice at 3 weeks after arterial wire injury (stained with H&E). Arrows indicate the internal elastic lamina. Scale bars: 100 μm.