Table 3.
Results from hierarchical mixed models for the longitudinal associations between FTO and MC4R variants with weight, BMI and height SDS
| (a) FTO rs9939609 | N | Mean (95% CI) per A-allele | P-value | |
|---|---|---|---|---|
| BMI SDS | Genotype (age 2 years) | 2466 | 0.01 (−0.04,0.06) | 0.6 |
| Genotype × age (2–20) (change per year 2–20 years) | 0.007 (0.003,0.010) | <0.001 | ||
| Genotype × age (20–53) (change per year 20–53 years) | −0.003 (−0.005, −0.001) | 0.001 | ||
| Weight SDS | Genotype (birth) | 2466 | 0.00 (−0.04,0.05) | 0.9 |
| Genotype × age (birth-20) (change per year 0–20 years) | 0.004 (0.001,0.007) | 0.005 | ||
| Genotype × age (20–53) (change per year 20–53 years) | −0.002 (−0.004, −0.000) | 0.02 | ||
| Height SDS | Genotype (age 2 years) | 2450 | −0.02 (−0.07,0.04) | 0.6 |
| Genotype × age (2–20)* (change per year 2–20 years) | −0.001 (−0.004,0.002) | 0.4 | ||
| (b) MC4R rs17782313 | N | Mean (95% CI) per C-allele | P-value | |
| BMI SDS | Genotype (age 2 years) | 2469 | 0.04 (−0.01,0.10) | 0.2 |
| Genotype × age (2–20) (change per year 2–20 years) | 0.002 (−0.002,0.006) | 0.3 | ||
| Genotype × age (20–53) (change per year 20–53 years) | −0.001 (−0.003,0.001) | 0.3 | ||
| Weight SDS | Genotype (birth) | 2469 | 0.04 (−0.01,0.09) | 0.1 |
| Genotype × age (birth-20) (change per year 0–20 years) | 0.005 (0.001,0.008) | 0.006 | ||
| Genotype × age (20–53) (change per year 20–53 years) | −0.002 (−0.004,0.000) | 0.05 | ||
| Height SDS | Genotype (age 2 years) | 2453 | 0.02 (−0.04,0.08) | 0.5 |
| Genotype × age (2–20)* (change per year 2–20 years) | 0.004 (0.001,0.007) | 0.02 | ||
Regression coefficients presented represent the main effect of genotype and genotype-by-linear age interactions.
*Final adult height (from measure at 36 years) was assumed to have been reached at 20 years.