Table 2.
Primary meta-analysis results
| Gene | Polymorphism | rs number | Contrast | OR | Studiesa | Allelesb | I2 |
|---|---|---|---|---|---|---|---|
| ACE | Indel | del→ ins | 1.12 (0.92–1.38) | 6 | 1746 | 0.00 | |
| ADRB2 | +46 AG | rs1042713 | A to G | 1.11 (0.75–1.65) | 5 | 2340 | 0.77 |
| ADRB2 | +79 CG | rs1042714 | C to G | 0.89 (0.51–1.41) | 5 | 2362 | 0.82 |
| EPHX1 | His139Arg | rs2234922 | A to G | 1.06 (0.91–1.23) | 15 | 9380 | 0.39 |
| EPHX1 | Tyr113His | rs1051740 | C to T | 1.11 (0.95–1.30) | 15 | 9374 | 0.65 |
| GSTP1 | Ile105Val | rs1695 | A to G | 1.09 (0.80–1.48) | 10 | 6228 | 0.83 |
| IL13 | +2044 GA | A to G | 1.00 (0.76–1.31) | 4 | 1276 | 0.00 | |
| IL13 | −1055 CT | C to T | 0.73 (0.35–1.56) | 3 | 1072 | 0.83 | |
| IL1B | −31 TC | C to T | 0.95 (0.62–1.46) | 4 | 1066 | 0.54 | |
| IL1B | −511 CT | C to T | 1.40 (0.94–2.07) | 5 | 884 | 0.71 | |
| IL4 | −33 CT | rs2070874 | C to T | 1.05 (0.79–1.38) | 4 | 1192 | 0.00 |
| IL6 | −174 GC | C to G | 0.98 (0.77–1.25) | 5 | 1354 | 0.00 | |
| LTA | +252 AG | A to G | 1.00 (0.78–1.28) | 4 | 1596 | 0.00 | |
| MMP9 | −1562 CT | C to T | 0.69 (0.44–1.09) | 4 | 1700 | 0.42 | |
| SERPINA3 | Ala9Thr | A to G | 0.80 (0.62–1.03) | 5 | 2676 | 0.45 | |
| SOD3 | Arg213Gly | rs1799895 | C to G | 1.97 (1.24–3.13) | 3 | 18392 | 0.00 |
| TGFB1 | −509 CT | rs1800469 | C to T | 1.05 (0.70–1.58) | 4 | 5030 | 0.85 |
| TGFB1 | +29 TC | rs1800470 | C to T | 0.73 (0.64–0.83) | 5 | 5256 | 0.00 |
| TIMP2 | +853 GA | rs2277698 | A to G | 0.59 (0.23–1.48) | 3 | 2102 | 0.89 |
| TNF | +489 GA | rs1800610 | A to G | 1.26 (0.96–1.66) | 6 | 2848 | 0.00 |
| TNF | −1031 TC | rs1799964 | C to T | 0.89 (0.67–1.17) | 3 | 1670 | 0.00 |
| TNF | −238 GA | rs361525 | A to G | 0.82 (0.57–1.19) | 5 | 3672 | 0.04 |
| TNF | −308 GA | rs1800629 | A to G | 1.19 (1.01–1.40) | 27 | 11812 | 0.34 |
| TNF | −857 CT | rs1799724 | C to T | 1.04 (0.77–1.40) | 3 | 1606 | 0.00 |
| TNF | −863 CA | rs1800630 | A to C | 0.91 (0.67–1.24) | 3 | 1646 | 0.00 |
| GSTM1 | Null | null → wt | 1.45 (1.09–1.92) | 8 | 2523 | 0.62 | |
| GSTT1 | Null | null → wt | 0.92 (0.73–1.15) | 5 | 1408 | 0.00 |
Meta-analyses performed for variants studied in three or more independent study populations. Random-effects meta-analysis performed using an allele-based model.
aNumber of case–control comparisons in which a variant has been tested for association with COPD.
bNumber of alleles included in meta-analysis (i.e. # of individuals x 2).