Table 2.
Details of SHBG levels in type 2 diabetes patients and normal glycaemic individuals in seven cross-sectional studies
| Type 2 diabetic patients |
Controls |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | Age (SD) | BMI (SD) | SHBG |
N | Age (SD) | BMI (SD) | SHBG |
|||
| Mean | SD | Mean | SD | |||||||
| Men | ||||||||||
| Abate et al. (34)a | 33 | 55 (9) | 27.6 (5.0) | 19.10 | 13.00 | 24 | 45 (9) | 28.2 (7.6) | 19.10 | 13.00 |
| Svartberg et al. (35)b | 55 | N/A | N/A | 43.70 | 21.40 | 1364 | N/A | N/A | 51.80 | 22.00 |
| Kalme et al. (36)c | 109 | N/A | N/A | 63.20 | 29.23 | 152 | N/A | N/A | 71.60 | 25.20 |
| InCHIANTId | 71 | 72.0 (9.4) | 27.80 (3.45) | 85.12 | 46.83 | 476 | 66.6 (16.2) | 26.91 (3.36) | 87.22 | 47.56 |
| TOTAL | 268 | 2016 | ||||||||
| SMD (95%CI) | −0.218 (−0.360, −0.076) | |||||||||
| Women | ||||||||||
| Jayagopal et al. (37)e | 12 | 62 (50–73) | 31.6 (25.1–35.7) | 38.80 | 18.20 | 11 | 56 (48–70) | 32.0 (26.6–44.4) | 42.20 | 17.10 |
| Stoney et al. (38)f | 42 | 64 (6.5) | 28.8 (5.2) | 27.80 | 20.50 | 42 | 63 (6.5) | 28.9 (4.5) | 40.30 | 26.12 |
| InCHIANTI (4) | 67 | 75.7 (9.8) | 29.34 (5.05) | 102.92 | 75.47 | 650 | 68.4 (15.8) | 27.04 (4.58) | 118.22 | 85.17 |
| TOTAL | 121 | 703 | ||||||||
| SMD (95% CI) | −0.264 (−0.475, −0.054) | |||||||||
Data are from individuals of European ancestry matched or corrected for BMI or waist circumference. Women are postmenopausal.
SMD, standardized mean difference; N/A, not available from original publications.
aControls selected to have the same range of BMI as cases. Controls include two individuals and cases include eight individuals of Hispanic ancestry.
bSvartberg et al., SHBG means and SDs are corrected for age and waist circumference.
cKalme et al., SHBG means and SDs are corrected for BMI.
dInCHIANTI SHBG values are geometric values derived from lnSHBG levels corrected for age and BMI.
eControls weight matched to cases. For BMI and age, median and range given.
fStoney et al. controls selected to match cases for BMI and age.