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. Author manuscript; available in PMC: 2010 Feb 4.
Published in final edited form as: Toxicology. 2008 Nov 11;256(1-2):53–64. doi: 10.1016/j.tox.2008.11.002

Fig. 4. Cyp2a4, Cyp2c40, and Cyp3a41 show differential patterns of regulation following treatment with NP or TCPOBOP in wild-type or CAR-null male and female mice.

Fig. 4

QPCR was performed as described in the Materials and Methods. On the X-axis, 0, 50, 75 refers to treatment with NP and TC refers to treatment with TCPOBOP. Data are expressed as mean ± SD (n = 5–6) for each of the different P450s in males and females. An asterisk indicates a significant difference from the untreated wild-type or CAR-null mice (p < 0.05). Statistical significance was determined by ANOVA followed with Fisher’s PLSD as the post-hoc test in NP-treated mice compared to their corresponding wild-type or CAR-null controls. Statistical significance was determined by Student’s t-tests in TC-treated mice compared to their corresponding wild-type or CAR-null controls.