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. 2008;31(3):215–230.

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Left panel) Extended reward and oversight system. Right panel) Cortical and subcortical regions in the “reward network” in which alcoholics have smaller volumes (covaried for age and total cerebral volume). Smaller volumes are circled.

NOTE: Amyg = amygdala; CGa, CGp = cingulate (anterior, posterior); dlPFC = dorsolateral prefrontal cortex; FOC = orbitofrontal cortex; Hipp = hippocampus; Hypo = hypothalamus; INS = insula; MB = mammillary bodies; NAC = nucleus accmbens; PHa, PHp = parahippocampal gyrus (ant, post); SC = subcallosal cortex; SLEA = sublentic-ular extended amygdala; TP = temporal pole; VntDC = ventral diencephalon.

SOURCE: Reprinted from Biological Psychiatry, Vol. 64, No. 3, Makris, N.; Oscar-Berman, M; Jaffin, S.K.; Hodge, S.M.; et al. Decreased volume of the brain reward system in alcoholism. Copyright 2008, with permission from Elsevier.