Table 2.
Characteristics of pediatric lupus nephritis cohort
| All n = 73 | Complete Responders n = 18 | Partial Responders n = 47 | Non-Responders n = 8 | P valueb | |
|---|---|---|---|---|---|
| Agea | 15.6 ± 3.4 | 15.3 ± 3.3 | 15.5 ± 3.4 | 16.4 ± 4.1 | 0.70 |
| BMI Z-score | 0.72 ± 1.42 | 0.42 ± 1.72 | 0.73 ± 1.32 | 1.3 ± 1.25 | 0.39 |
| Race | 0.05 | ||||
| Caucasian | 22 (30%) | 3 (16%) | 19 (40%) | ||
| African American | 47 (64%) | 13 (72%) | 26 (55%) | 8 (100%) | |
| Hispanic | 1 (2%) | 1 (6%) | - | ||
| American Indian | 3 (4%) | 1 (6%) | 2 (5%) | ||
| Baseline serum creatinine (mg/dl) | 1.73 ± 1.64 | 1.26 ± 1.2 | 1.4 ± 0.91 | 4.6 ± 2.9 | 0.001 |
| Baseline GFR (ml/min/1.73m2) | 81.3 ± 43.9 | 91.5 ± 38.9 | 86.8 ± 42.2 | 34.3 ± 35.6 | 0.005 |
| Hypertension | 47 (69%) | 13 (76%) | 27 (63%) | 7 (87%) | 0.34 |
| Baseline proteinuria (mg/day) | 3740 ± 3946 | 2802 ± 2999 | 4166 ± 4438 | 3777 ± 3211 | 0.44 |
| Histology class | 0.22 | ||||
| III | 12 (16%) | 6 (33%) | 6 (13%) | - | |
| IV | 54 (74%) | 11 (61%) | 36 (77%) | 7 (88%) | |
| V | 7 (10%) | 1 (6%) | 5 (10%) | 1 (12%) | |
| Relapsec | 23 (35%) | 6 (33%) | 17 (36%) | N/A | 0.54 |
| ESKD | 17 (24%) | 3 (17%) | 8 (18%) | 6 (75%) | 0.004 |
| Time to relapse (months) | 44.6 ± 32.2 | 42 ± 38.6 | 45.5 ± 30.8 | N/A | 0.66 |
| Time to ESKD (months) | 57.8 ± 47.3 | 93.3 ± 58.8 | 67.8 ± 41.4 | 26.7 ± 36.1 | 0.12 |
| Cytoxan | 59 (80%) | 16 (89%) | 37(78%) | 6 (75%) | 0.66 |
| Mycophenolate mofetil | 10 (14%) | 3 (17%) | 5 (11%) | 2 (25%) | 0.40 |
| Hydroxychloroquine | 32 (44%) | 12 (67%) | 19 (40%) | 1 (13%) | 0.04 |
| ACE Inhibitors | 43 (59%) | 14 (78%) | 24 (51%) | 5 (63%) | 0.16 |
a
Descriptive data represented as mean ± standard error or n (%).
b
P-values calculated using Fisher's exact test for categorical data and Kruskal-Wallis for continuous variables due to independent variable with more than two levels.
c
One patient in overall group who developed a partial response beyond first year and eventually relapsed. This patient was excluded from analyses on relapse data. Denominator is based on the total number of responders.