. Author manuscript; available in PMC: 2011 Jan 1.

Published in final edited form as: J Org Chem. 2010 Jan 1;75(1):86–94. doi: 10.1021/jo901752v

Table 1.

Cytotoxicity and Tubulin Assembly ED₅₀ Values^a

Compound	ED₅₀, nM MCF-7	ED₅₀, nM HCT-116	ED₅₀, μM Tubulin Assembly
14	>200	400	2.0
15	>200	500	2.5
16	>1000	>1000	>20
Epothilone B	1.0	1.8	2.0

Assays were carried out as described in reference ⁴¹.