Fig. 7.

a–d Session 4, case 24: LYG grade 3. The neoplastic growth shows angiocentricity and angioinvasiveness (a). At immunohistochemistry, lymphomatous cells express CD20 (b) and partly CD30 (b, inset) and are admixed with abundant CD3⁺ T lymphocytes (c). ISH reveals EBV integration (arrowed; d). e–h Session 4, case 16: EBV⁺ LPD mimicking DLBCL, leg type. The tumor infiltrates the deep dermis and subcutaneous tissue (e) and consists of large cells with plasmablastic features (f) that display high Ki-67 rate (g) and EBV integration at ISH (h). i–l Session 4, case 23: DLBCL associated with chronic inflammation (PAL). The lymphomatous population, showing immunoblastic/plasmablastic features (i), expresses CD20 (j), CD79a (k), and EBNA2 (l). m–p Session 4, case 32: HHV6⁺ THRLBCL. Scattered neoplastic cells (m) are comprised within a reactive population consisting of small lymphocytes and histiocytes (m). At immunohistochemistry, they express CD20 (n), are surrounded by CD3⁺ T lymphocytes (n, inset) and turn positive for the virus-associated antigen HIND (o). Electron microscopy shows viral particles consistent with HHV6 (p)