Table 1. Benchmarking results for ODM, NRM, MODM and LOLCAT Method.

System Parameters Runtimes(s)
ID	# Rxns.	# Species	ODM	NRM	MODM	LOLCAT
A	2040	236	8.45, 0.04	25.52, 5.75	25.08, 0.12	3.06, 0.14
B	11492	5092	61.08, 0.17	162.68, 6.15	64.21, 0.22	1.68, 0.04
C	35003	11402	152.18, 0.64	374.73, 4.63	166.06, 0.46	3.73, 0.06
D	84301	15087	374.66, 2.30	720.35, 62.32	390.85, 1.41	4.73, 0.13
E	162150	14766	640.72, 3.01	964.49, 99.97	623.39, 1.58	1.88, 0.04
F	292190	15287			2527.93, 61.09	9.30, 0.09

Six versions of the Yeast Pheromone Model [10] were benchmarked. Slowdown factors are mean time normalized against the performance of LOLCAT Method for each model. The “” in the last entry for ODM and NRM indicates that those simulations could not be run because the dependency graph consumed more than the RAM and swap space, roughly 20 GB, of the host machine. The varying structure of the simulated system may account for the non-uniform scaling of runtimes.