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. 2010 Jan 5;5(1):e8588. doi: 10.1371/journal.pone.0008588

Figure 2. Change of Treg Cells with Aging in Spleen and LNs of CCR7 −/− Mice.

Figure 2

(A) The number of Foxp3+CD4+ T cells in spleen and LNs from WT and CCR7 −/− mice from 2 to 6 months of age was analyzed by flow cytometer. Data are means±s.e.m. of 7 to 10 mice in each group. *p<0.05, versus the cell number at 2 mo (upper panel), *p<0.05, **p<0.005, versus WT. (B) Foxp3 expressions of CD4+ T cells in PBMC, spleen, LNs, and thymus from WT and CCR7 −/− mice at 2 and 6 months of age were analyzed by flow cytometer. (C) CD4+Foxp3+ cells in cervical lymph node were analyzed by confocal microscopy. Figures and photos are representative of 3 to 7 mice in each group.