Table 1.
Parameters used in the Monte Carlo simulation studies
| Metabolite | WM | GM | ||||
|---|---|---|---|---|---|---|
| Concentration (a.u.) | T1 (s) | SNR at TR = 8s | Concentration (a.u.) | T1 (s) | SNR at TR = 8s | |
| NAA singlet (3 equivalent protons) | 7.5 | 1.55 | 2 | 9 | 1.45 | 2 |
| Cho (9 equivalent protons) | 1.8 | 1.2 | 1.44 | 1.5 | 1.2 | 1 |
| Cr-CH3 (3 equivalent protons) | 5.2 | 1.3 | 1.39 | 7.7 | 1.4 | 1.71 |
| mI | 3.8 | 1.1 | 0.91 (at 3.56ppm) | 5 | 1.1 | 0.99 |
| Glu (T1 not estimated) | 7 | 1.3 | / | 9 | 1.3 | / |
| Background signal | WM/GM | ||
|---|---|---|---|
| α | ω (ppm) | SNR at TR = 8s | |
| Nine gaussian components, time domain model: Σ9i=1ai exp(jωt)exp(−β2t2)T1 = 0.2s and β = 50 Hz for all the components | 2.5 | 1.88 | 0.21 |
| 15 | 2.08 | 1.29 | |
| 2.5 | 2.39 | ||
| 2.5 | 2.55 | ||
| 2.5 | 2.71 | ||
| 10 | 3.09 | 0.86 | |
| 5 | 3.5 | 0.43 | |
| 5 | 3.66 | ||
| 10 | 3.91 | ||
The macromolecular background components were chosen to make the background signal resemble the patterns shown in Ref. [3] a.u. arbitrary unit, WM white matter, GM gray matter