Fig. 1.

Photomicrographs of retinal cryosections from TUDCA-treated rd1 mice. Pde6b ^rd1 (rd1) mice were subcutaneously injected with vehicle or TUDCA (500 mg/kg body weight every 3 days). Injections started at postnatal day (P) 9 and continued to P21, at which point animals were killed, and retinal paraffin sections were cut and stained with hematoxylin and eosin (H&E-stained). Vehicle-treated retinas showed the expected near-total loss of ONL cells. Conversely, TUDCA-treated retinas had varied, but more organized morphology ranging from very little ONL to thick ONL and in some instances the preservation of what appear to be photoreceptor outer segments. RPE: retinal pigment epithelium; IS/OS: inner segment/outer segment; ONL: outer nuclear layer; OPL: outer plexiform layer; INL: inner nuclear layer; IPL: inner plexiform layer; GCL: ganglion cell layer