Fig. 2.

Effect of TUDCA treatment on number of photoreceptor cells in P18 and P30 rd10 mice. rd10 were injected subcutaneously with vehicle or TUDCA (500 mg/kg) every 3 days starting at P6. At P18 and P30 mice were killed, and retinal paraffin sections were prepared and H&E-stained. Outer nuclear layer nuclei were counted in two regions per section and were assumed to reflect number of photoreceptor cells. Each region spanned 400 µm starting from a point 400 µm from either side of the optic nerve. TUDCA treatment significantly preserved the number of photoreceptors at both postnatal days. Of note is that TUDCA treatment delayed the loss of photoreceptor cells by 12 days over the course of the degeneration to P30