Fig. 3.

Effect of TUDCA treatment on retinal morphology and TUNEL in P18 rd10 mice. Fluorescence microscopy using a B-2A emission fluorescence filter allows observation of the preservation of photoreceptor inner segments (IS) and outer segments (OS) present in TUDCA- (right) versus vehicle-treated retina sections (left). TUNEL-positive nuclei (green/yellow signal) are seen to be abundant in vehicle-treated sections, but rare retinas from TUDCA-treated mice. TUDCA treatment provided significant preservation of photoreceptor nuclei number in the outer nuclear layer (ONL). Treatment had no discernable effect on the inner nuclear layer (INL) or ganglion cell layer (GCL). Image reprinted with permission from Ref. [81]