Fig. 6.

Effect of TUDCA treatment on retinal morphology in rd10 and wild-type mice at P30. Retinal micrographs from P30 wild-type C57BL/6 mice treated with TUDCA (a) or vehicle (b) and from rd10 mice treated with TUDCA (c) or vehicle (d). TUDCA treatment has no effect on wild-type retinal morphology. In rd10 mice, the photoreceptor layer has been reduced to approximately one row of nuclei (d), but TUDCA treatment preserved three to four rows of nuclei (c). c and d Clear differences in the thicknesses of the ONL, outer segments (OS), and inner segments (IS), with TUDCA treatment demonstrating a delay of retinal degeneration. e and f Plots of the total number of photoreceptors at each retinal location from wild type and rd10 mice with reference to the optic nerve head (ONH). The inset is a diagram of the retina and optic nerve and the areas from which cells numbers were sampled. The TUDCA-treated mice have significantly more photoreceptors across all areas sampled than vehicle-treated mice. Image reprinted from Ref. [82]