Fig. 7.

Effect of TUDCA on LIRD mouse retina morphology and apoptosis: 24-h post-light exposure. Mice were subcutaneously injected with either vehicle or TUDCA (500 mg/kg), exposed to 10,000 lx of white light for 7 h, then returned to maintenance lighting conditions. Mice were killed 24 h later, and paraffin retina sections were prepared and assayed for fluorescent TUNEL by confocal microscopy. Representative composite confocal micrographs for vehicle (left) versus TUDCA (right) treatments are shown. Bright-light-exposure-induced massive apoptosis (yellow signal) and morphological damage in photoreceptor cells and retinal outer nuclear layer of vehicle- (left) but not TUDCA-treated eyes (right). Image reprinted with permission from Ref. [81]