. 2008 Aug 5;12(3):229–239. doi: 10.1007/s10151-008-0426-6

Table 3.

Postoperative pain, postoperative analgesic use, wound healing, return to normal activities and follow-up time reported in randomized controlled trials comparing LIgaSure (LS) with conventional haemorrhoidectomy (CH)

Reference	Postoperative pain score^d	Postoperative analgesic use	Wound healing (days)	Retum to normal activities	Median follow-up (months)
19	Median (range), day 1:LS5(1–9), CH 7 (4–9)^a	NR^a	NR	Back at work at 3 weeks^a: LS 17 of 20, CH 15 of 20	LS 3, CH 3; long-term^b: LS 37, CH 36
20	Median (range), day 1:LS4.7(2–8), CH 5.2 (2–8)^a	Median (range) number used: LS 14.1 (10–20), CH 16.8 (12–22)*	Median (range): LS 16.3 (14–22), CH 37.5 (25–52)*	Median days (range): LS 8.3 (5–14), CH 18.3 (10–30)*	LS 6, CH 6
21	Median (range): LS 5.2 (2–8), CH 4.6 (1–8.4)^a	Median (range) 7-days tramadol (mg): LS 850 (0–2,750), CH 1600 (0–2100)*	NR	NR	LS1.5, CH1.5; long-term^c: LS 15, CH 16
12	Mean (SD), day 1:LS2.3(0.8), CH 6.9 (0.8)*	Mean (SD) no. of dipyrone tablets: LS 2.1 (0.5), CH 4.6 (0.8)*	LS “better and faster”	NR	LS 6, CH 6
22	Mean (SD): LS 4.5 (2), CH 4.0 (2.3)^a	Mean (SD) pethidine injections^a and dologesic tablets^a: LS 0.7 (1) and 12.6 (10.7), CH 1.2 (2.1) and 13.3 (11.1)	CH impaired at 4 weeks	Mean (SD) days: LS 11.6(5.4), CH 10.3 (4.5)^a	LS 3, CH 3
13	Mean (SD), day 1:LS6.5(0.4), CH 8 (0.5)*	NR	Both groups “complete after 6 weeks”	Median: LS 1–2 weeks, CH 1–2 weeks^a	LS 4, CH 4
23	Median (range), day 1:LS2.5(0–6), CH 7.5 (6–9)*	NR	NR	NR	LS 3, CH 3
16	Mean (SEM): LS 5.1 (0.2), CH 7.2 (0.2)*	Parenteral: LS 12, CH 32*	Both groups “complete after 6 weeks”^a	Mean days (SEM): LS 8.8 (0.2), CH 13.7 (0.4)*	LS 2, CH 2
24	Median, day 1: LS3.65, CH3.14^a	Mean total dose (mg) of pethidine: LS 65, CH75^a	Both groups “complete after 4 weeks”^a	NR	LS 1, CH 1
8	Mean (range), day 1:LS 1.5(0–3), CH 3.3 (2–6)*	NR	Mean (range): LS 14.8 (10–21), CH 25.6 (14–40)*	Mean (range): LS 12.3 (5–21), CH 16.4 (10–30)*	LS 36, CH 36
9	Median, day 1: LS 2.8, CH 3.4	Median number of tablets, day 3: LS 0.5, CH 1*	Incomplete healing after 4 weeks: LS 9 patients, CH 8 patients^a	Median days: LS 10.8, CH 14.5*	LS 1, CH 1

NR, not reported

*Significant difference between the two groups

^aNo significant difference between the two groups

^bMedian follow-up time, Peters et al. [16]

^cMedian follow-up time, Lawes et al. [17]

^dPostoperative pain score: 0 no pain, 10 most severe pain