Table 2.

Population Characteristics by Margins for DCIS According to Central Pathology Review

Parameter	Margin at DCIS						P
	Positive		Close		Negative
	No.	%	No.	%	No.	%
No. of patients	111		216		478
Volume of excision biopsy specimen, cm3
Median	110.0		120.0		120.0		.81720
Range	4.5-567.0		5.6-1,800.0		1.3-1,584.0
Largest diameter, mm
Median	15.0		15.0		15.0		.13729
Range	4.0-40.0		4.0-40.0		4.0-40.0
Age at random assignment, years
Median	51		52		54		.00997
Range	28-70		27-69		28-76
Younger than 50	52	47	84	39	154	32	.0122
50-60	42	38	78	36	186	39
Older than 60	17	15	54	25	138	29
N+ according to local pathology	30	27	55	26	116	25	.8314
Postmenopausal	57	51	125	58	292	61	.1611
Receptor status
Estrogen+	54	68	103	64	277	77	.0029
Progesterone+	44	61	92	63	219	68	.3858
Systemic treatment	46	41	88	41	162	34	.1218
Mitotic activity index
< 10	75	68	133	62	377	79	< .0001
10-19	16	14	50	23	60	13
≥ 20	20	18	32	15	39	8
Histology
Ductal	88	79	177	82	391	82	.8108
Mixed pattern	23	21	39	18	87	18
Differentation of the invasive tumor
Low	50	46	85	41	247	53	< .0001
Intermediate	21	19	66	32	136	29
High	38	35	58	28	80	17
Extensive intraductal component	59	53	46	21	44	9	< .0001
Differentiation of DCIS
Low	52	47	73	34	122	26	< .0001
Intermediate	27	24	91	42	244	51
High	32	29	52	24	110	23
Vascular invasion
None	80	72	142	66	353	74	.125
Present	23	21	45	21	75	16
Doubtful	8	7	29	13	48	10

Abbreviation: DCIS, ductal carcinoma in situ.