Table 4.

Univariate Analysis for Local Relapse in Patients With 0 or 16 Gy Boost

Contrast by Factor	P	Hazard Ratio	95% CI
Age > 50, yes v no	< .0001	0.40	0.28 to 0.57
N+ according to local pathology, N+ v N−	.2585	0.77	0.48 to 1.22
Systemic treatment (chemotherapy or tamoxifen), yes v no	.0088	0.57	0.38 to 0.87
Volume of excision biopsy specimen, cm3	.1068	1.00	1.00 to 1.00
Treatment, no boost v boost 16 Gy	.0008	1.86	1.29 to 2.68
Vascular invasion, yes v no	.9715	0.99	0.65 to 1.50
Extensive intraductal component, yes v no	.8975	1.04	0.57 to 1.90
Histology
Lobular v ductal	.4451	0.72	0.32 to 1.66
Mixed pattern v ductal	.3184	0.72	0.37 to 1.38
Other v ductal	.6439	0.88	0.50 to 1.54
Histologic grade
Intermediate v high	.0320	0.60	0.37 to 0.96
Low v high	.0003	0.46	0.31 to 0.70
Ductal component involved, yes v no	.5254	1.17	0.72 to 1.89
Lobular component involved, yes v no	.2482	0.73	0.43 to 1.24
Mitotic activity index, < 10 v > 10	.0267	0.66	0.45 to 0.95
Margin involved of DCIS, not involved v involved	.3710	0.82	0.53 to 1.27
Margin involved of DCIS/invasive tumor, not involved v involved	.6779	0.92	0.64 to 1.34
Margin involved of invasive tumor, not involved v involved	.4127	1.20	0.78 to 1.84
Margin of DCIS
No DCIS v positive	.4862	0.78	0.38 to 1.58
Close v positive	.9276	0.97	0.46 to 2.03
Negative v positive	.8362	0.93	0.48 to 1.81
Grade of DCIS
No DCIS v high grade	.9640	1.02	0.51 to 2.03
Low v high	.1826	1.57	0.81 to 3.06
Moderate v high	.7437	1.12	0.58 to 2.16
Margin of invasive tumor
Negative v close	.6589	1.11	0.71 to 1.73
Incomplete v close	.3191	0.48	0.11 to 2.03
Estrogen positive, yes v no	.0330	0.63	0.41 to 0.96
Progesterone positive, yes v no	.4286	0.84	0.54 to 1.30

Abbreviation: DCIS, ductal carcinoma in situ.