Table 3.
Genes Differentiating Secondary Imatinib Resistance From Newly Diagnosed CML With Imatinib Response
| Gene | Median Normalized Expression Levels |
t-test P | t-test P (adjusted) | |
|---|---|---|---|---|
| CML With Secondary Imatinib Resistance (n = 23) | CML With Imatinib Response (n = 48) | |||
| TEC | 0.207 | 0.588 | < .001 | < .001 |
| ABL1 | 0.864 | 1.437 | < .001 | < .001 |
| PTPN22 | 4.733 | 14.450 | < .001 | < .001 |
| CEBPA | 0.658 | 1.592 | < .001 | < .001 |
| RUNX3 | 1.662 | 0.683 | < .001 | < .001 |
| LYN | 18.375 | 53.190 | < .001 | < .001 |
| BTK | 1.325 | 2.104 | < .001 | < .001 |
| JAK2 | 1.648 | 2.734 | < .001 | < .001 |
| CD34 | 0.012 | 0.177 | < .001 | < .001 |
| STAT5A | 1.643 | 1.000 | < .001 | < .001 |
| ABCB1 | 0.206 | 0.045 | < .001 | < .001 |
| ABCC1 | 0.884 | 0.473 | < .001 | < .001 |
| CSF2 | 0.002 | 0.001 | .0252 | .2015 |
| PTGS1 | 0.599 | 0.378 | .0097 | .087 |
| SLC22A1 | 0.328 | 0.175 | .0365 | .2554 |
| FZD7 | 0.022 | 0.029 | .1548 | .5621 |
| SLC22A3 | 0.000 | 0.000 | .0685 | .4111 |
| STAT3 | 6.229 | 6.592 | .093 | .465 |
| RUNX1 | 3.567 | 3.546 | .1405 | .5621 |
| STAT5B | 2.828 | 2.532 | .7363 | 1 |
| ABCG2 | 0.007 | 0.007 | .9292 | 1 |
Abbreviation: CML, chronic myelogenous leukemia.