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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Pharmacol Ther. 2009 Sep 23;124(3):324–335. doi: 10.1016/j.pharmthera.2009.09.002

Figure 1.

Figure 1

Schematic diagram of a hypothetical eukaryotic gene promoter region with the canonical elements and binding proteins that regulate gene expression. In general, the TFIID complex binds to one or several of these core promoter elements to actively recruit the Pol II holoenzyme and initiate transcription. The TATA box and Inr elements are able to initiate transcription individually, but often operate synergistically with other motifs to recruit TFIID. This core promoter region is often transcriptionally silent and with additional activating elements forms the minimal promoter for transcriptional efficiency. [Adapted from Smale and Kadonaga, 2003; Deng and Roberts 2006; Thomas and Chiang, 2006; and Sadhale et al., 2007.]