Figure 1.

Dexamethasone ameliorates renal dysfunction and attenuates the histologic damage of rat renal IRI. (A) The increase in serum creatinine at 24 h after reperfusion after renal IRI is abrogated by dexamethasone (Dex, 3 mg/kg, intraperitoneal) administered either preischemia or on release of clamps. n = 12 per group. (B) Renal histopathology. Hematoxylin and eosin–stained sections are from the outer medulla (representative images of at least three experiments). (C) Quantitative scores of tubular injury in the outer medulla. The analysis was performed under the same magnification for respective groups. (D) Neutrophil accumulation within the interstitium of the kidney was significantly less in I/R+Dex rats versus I/R+V (V, vehicle) rats at 24 h after reperfusion. (numbers/10 high-power fields). *P < 0.05, ** P < 0.01.