Table 1.

Effects of pioglitazone on renal function and glucose and lipid metabolism in 24-mo-old rats

	Urine Proteina(mg/24 h)	Ccr(ml/min)	Glucose(mg/dl)	Insulin(ng/ml)	Cholesterol(mg/dl)	HDL-Cholesterol(mg/dl)	LDL-Cholesterol(mg/dl)	Triglycerides(mg/dl)
Control(n = 7)	648.50 ± 79.52	0.38 ± 0.09	150.67 ± 10.44	0.52 ± 0.06	205.56 ± 23.45	40.22 ± 5.16	116.04 ± 10.71	246.44 ± 26.22
Pioglitazone(n = 10)	227.56 ± 71.63b	0.83 ± 0.16b	111.38 ± 14.81b	0.80 ± 0.11	118.50 ± 5.46b	35.38 ± 6.08	64.83 ± 3.16b	91.50 ± 4.81b

^aBaseline proteinuria at 18 months before treatment was 51.59 ± 12.80 mg/24 h.

^bP < 0.05 versus control.