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. 2009 Nov;20(11):2328–2337. doi: 10.1681/ASN.2008121224

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Copyright © 2009 by the American Society of Nephrology

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Figure 4. — Hypoplasia in p53^−/− kidneys is shown. (A) In situ hybridization for Spry1 was done on E12.5 metanephroi. Branch and tip formation are lagging in the p53^−/− metanephros in comparison with the age-appropriate branching observed in a p53^+/+ littermate. There was no change in Spry1 mRNA levels. (B) Decreased proliferation in p53-null kidneys was visualized by phospho-H3 antibody staining compared with kidney section from WT littermate. (C) UB tip numbers were counted in four litters from p53^+/− pairings. (D) The number of tips was consistently lower in p53^−/− (yellow bar) versus p53^+/+ metanephroi (purple bar), with the null metanephroi showing 30% fewer tips than the WT.