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. 2009 Dec 28;120(1):369–378. doi: 10.1172/JCI40801

Figure 5. Computer simulations of Nav1.5 currents and cardiac myocyte APs.

Figure 5

(A) Simulated Nav1.5 (black trace) and Nav1.5-F1486L (blue trace) currents elicited by a voltage step from –100 mV to +10 mV. (B) Simulated resurgent currents generated by model Nav1.5 (black trace) and Nav1.5-F1486L (blue trace) conductances. Model currents were elicited with the standard resurgent current voltage protocol shown in Figure 2E. The modeled resurgent current was 0.9% of the peak current for Nav1.5 and 1.7% of the peak current for Nav1.5-F1486L. (C) Simulated APs from a modeled cardiac myocyte. There was little difference between the APs of a model cell with Nav1.5 that did not include resurgent currents (black trace) and those of a cell with Nav1.5 that did include resurgent currents (green trace). Nav1.5-F1486L simulated without resurgent current generation broadened the AP (red trace), and this effect was exacerbated in the simulation of Nav1.5-F1486L with resurgent current generation (blue trace).