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Involvement of MMP9 in intestinal adenoma formation. (A) The effects of the MMP9-specific inhibitor, ZA, on intestinal adenoma formation in ApcMin/+ mice (n=5–7 per genotype). *P<0.05. (B) Suppression of MMP9 gelatinase activity by ZA in vivo. Lysates from spleens of control and ZA-treated ApcMin/+ mice were subjected to gelatine zymography for MMP9. MMP9, matrix metalloproteinase 9; ZA, zoledronic acid; zymo, gelatin zymography.
