Table 4.
Selected Acute Grade 2 to 4 Toxicities (highest grade per patient)
| Toxicity | Grade 2 |
Grade 3 |
Grade 4 |
|||
|---|---|---|---|---|---|---|
| No. of Patients | % | No. of Patients | % | No. of Patients | % | |
| Induction chemotherapy | ||||||
| Nonhematologic | ||||||
| Arthralgia/myalgia | 6 | 13 | ||||
| Anorexia | 4 | 9 | 1 | 2 | ||
| Diarrhea | 4 | 9 | 4 | 9 | ||
| Fatigue | 19 | 40 | 1 | 2 | ||
| Nausea/vomiting | 6 | 13 | ||||
| Pruritus | 3 | 6 | ||||
| Rash/folliculitis | 18 | 38 | 21 | 45 | ||
| Sensory neuropathy | 7 | 15 | 1 | 2 | ||
| Allergic reaction | 2 | 4 | ||||
| Hematologic | ||||||
| Neutropenia | 11 | 23 | 9 | 19 | 1 | 2 |
| Anemia | 4 | 9 | ||||
| Thrombocytopenia | — | — | — | |||
| Definitive therapy* | ||||||
| Anorexia | 4 | 9 | 3 | 6 | ||
| Dry mouth | 14 | 30 | 2 | 4 | ||
| Taste alteration | 15 | 32 | 2 | 4 | ||
| Fatigue | 7 | 15 | 2 | 4 | ||
| Dehydration | 3 | 6 | ||||
| Mucositis | 7 | 15 | 36 | 77 | 1 | 2 |
| Nausea/vomiting | 2 | 4 | 3 | 6 | ||
| Rash/desquamation | 6 | 13 | ||||
| Tinnitus | 3 | 6 | ||||
| Sensory neuropathy | 2 | 4 | ||||
| Febrile neutropenia | 1 | 2 | ||||
NOTE. The attribution to induction or definitive treatment was according to the time of onset.
*
Includes patients treated with radiation alone (n = 23), chemoradiation with various regimens (n = 23), and surgery followed by adjuvant radiation (n = 1).