. 2010 Jan;21(1):145–152. doi: 10.1681/ASN.2009030287

Table 3.

Two-year risks of outcomes by treatment and CKD status (eGFR, ml/min per 1.73 m²) in patients with moderate-grade ICA stenosis (50 to 69%)

Parameter	Medical Risk (%)(n = 151)^a(n = 266)^b	Surgical Risk (%)(n = 156)^a(n = 270)^b	RRR (%)	Absolute Risk Difference (%; 95% CI)	P	Interaction Test (P)
Parameter	Medical Risk (%)(n = 151)^a(n = 266)^b	Surgical Risk (%)(n = 156)^a(n = 270)^b	RRR (%)	Absolute Risk Difference (%; 95% CI)	P	Risk Difference	RRR
Ipsilateral stroke^c
eGFR <60	16.0	11.0	31.2	5.0 (−2.8 to 12.8)	0.34	0.92	0.94
eGFR ≥60	13.6	9.1	33.1	4.5 (−1.0 to 9.9)	0.15
Death (any cause)
eGFR <60	10.7	10.4	2.8	0.3 (−6.7 to 7.3)	0.99	0.89	0.88
eGFR ≥60	5.1	5.3	−3.9	−0.2 (−4.1 to 3.6)	0.88
Any stroke, MI, or vascular death
eGFR <60	29.9	19.7	34.1	10.2 (−1.3 to 18.4)	0.08	0.26	0.35
eGFR ≥60	21.5	18.2	15.3	3.3 (−2.7 to 11.1)	0.45

Medical and surgical groups were compared using a log-rank test. RRR, Relative Risk Reduction.

^aeGFR <60 ml/min per 1.73 m².

^beGFR ≥60 ml/min per 1.73 m²

^cTo provide a more conservative estimate of the benefits of endarterectomy, the outcome “ipsilateral stroke” includes any stroke and any death within 32 d of randomization (30 d postoperatively; median time from randomization to surgery was 2 d).