Table 1.
Graft outcome | Failed grafts (n = 9) | Surviving grafts (n = 11) | P |
---|---|---|---|
TGF-β1 | 1.26 [0.03 to 6.95] | 2.44 [1.03 to 3.60] | 0.0367 |
TNF-α | 5.12 [0.19 to 46.94] | 4.91 [2.31 to 17.40] | 0.4060 |
MCP-1 | 0.23 [0.02 to 1.73] | 0.33 [0.09 to 0.61] | 0.4938 |
RANTES | 15.02 [0.83 to 66.49] | 47.00 [8.96 to 159.65] | 0.0118 |
HMOX1 | 1.18 [0.70 to 25.06] | 1.35 [0.14 to 9.07] | 0.2650 |
CD3 | 13.65 [0.57 to 17.93] | 18.55 [7.65 to 28.54] | 0.1091 |
CD20 | 4.17 [1.00 to 32.63] | 53.65 [7.72 to 278.29] | 0.0035 |
IgJ | 0.85 [0.18 to 6.19] | 7.27 [0.73 to 212.78] | 0.0086 |
FoxP3 | 1.20 [0.29 to 5.00] | 5.34 [1.73 to 25.51] | 0.0200 |
GZMB | 4.01 [0.15 to 6.74] | 6.64 [1.72 to 20.31] | 0.0955 |
PRF | 10.04 [1.28 to 17.82] | 17.65 [6.98 to 48.17] | 0.0763 |
FoxP3/CD3 | 0.16 [0.11 to 2.13] | 0.22 [0.09 to 1.82] | NS |
GZMB/CD3 | 0.34 [0.20 to 0.60] | 0.31 [0.11 to 1.10] | NS |
PRF/CD3 | 1.08 [0.75 to 2.26] | 0.82 [0.35 to 4.27] | NS |
Relative quantities of specific gene expression relative to thatof the housekeeping gene HPRT and the calibrator sample are expressed asmedians [range]. Results reflect the gene expression patterns at thetime of diagnosis of early AMR and prior to therapy. One patient who died withfunctioning graft was not included in the analysis. The critical P fromBonferroni correction for multiple testing in Sankoh's modification is 0.01.Statistically significant values are represented in boldface type.