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. 2010 Jan;21(1):173–180. doi: 10.1681/ASN.2008121268

Table 1.

Quantitative intrarenal mRNA expression in early acute AMR

Graft outcome Failed grafts (n = 9) Surviving grafts (n = 11) P
TGF-β1 1.26 [0.03 to 6.95] 2.44 [1.03 to 3.60] 0.0367
TNF-α 5.12 [0.19 to 46.94] 4.91 [2.31 to 17.40] 0.4060
MCP-1 0.23 [0.02 to 1.73] 0.33 [0.09 to 0.61] 0.4938
RANTES 15.02 [0.83 to 66.49] 47.00 [8.96 to 159.65] 0.0118
HMOX1 1.18 [0.70 to 25.06] 1.35 [0.14 to 9.07] 0.2650
CD3 13.65 [0.57 to 17.93] 18.55 [7.65 to 28.54] 0.1091
CD20 4.17 [1.00 to 32.63] 53.65 [7.72 to 278.29] 0.0035
IgJ 0.85 [0.18 to 6.19] 7.27 [0.73 to 212.78] 0.0086
FoxP3 1.20 [0.29 to 5.00] 5.34 [1.73 to 25.51] 0.0200
GZMB 4.01 [0.15 to 6.74] 6.64 [1.72 to 20.31] 0.0955
PRF 10.04 [1.28 to 17.82] 17.65 [6.98 to 48.17] 0.0763
FoxP3/CD3 0.16 [0.11 to 2.13] 0.22 [0.09 to 1.82] NS
GZMB/CD3 0.34 [0.20 to 0.60] 0.31 [0.11 to 1.10] NS
PRF/CD3 1.08 [0.75 to 2.26] 0.82 [0.35 to 4.27] NS

Relative quantities of specific gene expression relative to thatof the housekeeping gene HPRT and the calibrator sample are expressed asmedians [range]. Results reflect the gene expression patterns at thetime of diagnosis of early AMR and prior to therapy. One patient who died withfunctioning graft was not included in the analysis. The critical P fromBonferroni correction for multiple testing in Sankoh's modification is 0.01.Statistically significant values are represented in boldface type.