Table 2.

Quantitative intrarenal mRNA expression within grafts that suffered from early TCMR

Graft outcome	Failed grafts (n = 4)	Surviving grafts (n = 37)	P
TGF-β1	2.69 [0.04 to 5.46]	1.92 [0.01 to 7.03]	0.5762
TNF-α	3.70 [0.99 to 24.55]	6.07 [0.11 to 30.90]	0.5657
MCP-1	0.42 [0.22 to 1.62]	0.39 [0.12 to 1.66]	0.4394
RANTES	30.72 [9.39 to 180.12]	63.82 [4.13 to 184.98]	0.5730
HMOX1	0.82 [0.12 to 16.21]	0.79 [0.01 to 13.80]	0.5831
CD3	13.09 [2.00 to 17.00]	26.28 [0.29 to 199.68]	0.0809
CD20	20.63 [2.90 to 31.13]	108.46 [7.09 to 1519.93]	0.0033
IgJ	1.62 [1.18 to 2.73]	6.76 [0.37 to 220.48]	0.0003
FoxP3	4.38 [0.83 to 6.30]	9.99 [1.56 to 33.25]	0.0503
GZMB	9.26 [8.92 to 9.61]	8.16 [0.0005 to 69.20]	0.2732
PRF	22.24 [2.16 to 42.33]	14.96 [0.007 to 89.60]	0.9183
FoxP3/CD3	0.41 [0.26 to 0.48]	0.48 [0.12 to 1.19]	NS
GZMB/CD3	2.51 [0.57 to 4.46]	0.26 [0.00001 to 2.56]	NS
PRF/CD3	1.79 [1.08 to 2.49]	0.47 [0.0002 to 6.54]	NS

Relative quantities of specific gene expression relative to that of the housekeeping gene HPRT and the calibrator sample are expressed as median [range]. Samples for gene expression analyses were obtained prior to the antirejection therapy. The critical P from Bonferroni correction for multiple testing in Sankoh's modification is 0.01. Statistically significant values are represented in boldface type. Two patients who died with functioning graft were not included in the analysis.