Figure 2. Effect of intravenous injection of VA7-EGFP on the growth of subcutaneous U87Fluc tumor xenografts.

(A) U87Fluc cells (5×10⁶) were implanted subcutaneously in nude mice and when the tumors had grown to an average size of 100 mm³, the animals were given a single intravenous injection of either PBS or 1×10⁶ PFU of VA7-EGFP. In another two groups, the tumors were allowed to grow until they reached an average size of 450 mm³ and the animals were given either a single intravenous injection of 1×10⁶ PFU of VA7-EGFP or three injections of the virus at 7-day intervals, each 1×10⁶ PFU. (B) Kaplan-Meier survival analysis of mice with subcutaneous U87Fluc xenografts and treated with either PBS or intravenous injections of VA7-EGFP.