Table 2.
Genes with overlapping but opposite alteration in ISO-treated and exercise mouse hearts
| Gene ID | Gene Name | Gene Symbol | Function | ISO | Swim | ||
|---|---|---|---|---|---|---|---|
| FC | p | FC | p | ||||
| BE133150 | ESTs | NA | Unknown | 2.0 | 0.002 | -2.1 | 0.011 |
| BC019553 | cDNA | NA | Unknown | 2.6 | 0.002 | -2.9 | 0.002 |
| BI180630 | ESTs | NA | Unknown | 2.0 | 0.007 | -2.1 | 0.007 |
| BM234799 | cDNA | NA | Actin cytoskeleton organization | 1.7 | 0.009 | -2.0 | 0.006 |
| BB283973 | cDNA | NA | Unknown | -3.1 | 0.010 | 2.4 | 0.020 |
| AW537707 | Actin, beta, cytoplasmic | Actb | Non-muscle cytoskeletal constituent | -3.0 | 0.009 | 1.8 | 0.009 |
| NM_007398 | Adenosine deaminase | Ada | Smooth muscle contraction; immune response | 2.2 | 0.004 | -1.9 | 0.005 |
| AV229424 | Collagen, type V, alpha 2 | Col5a2 | Extracellular matrix structural constituent | 2.2 | 0.022 | -2.2 | 0.005 |
| NM_010188 | Fc receptor, IgG, low affinity III | Fcgr3 | Antigen processing and presentation via MHC class I | 2.1 | 0.006 | -1.6 | 0.003 |
| BC004724 | Fibronectin 1 | Fn1 | Acute-phase response; cell-matrix adhesion | 2.3 | 0.020 | -1.7 | 0.005 |
| AK012898 | Glycine/arginine rich protein 1 | Grrp1 | Unknown | 3.5 | 0.005 | -2.3 | 0.005 |
| BB269715 | Hypoxia inducible factor 1, alpha subunit | Hif1a | Angiogenesis; neural crest cell migration; response to hypoxia | -1.9 | 0.002 | 2.0 | 0.002 |
| BE995678 | Heat shock protein 90, beta (Grp94), member 1 | Hsp90b1 | Stress response | -8.4 | 0.009 | 3.4 | 0.014 |
| NM_030127 | HtrA serine peptidase 3 | Htra3 | Regulation of cell growth | 1.8 | 0.006 | -2.2 | 0.006 |
| BC003209 | Integrator complex subunit 3 | Ints3 | snRNA processing | 2.2 | 0.006 | -2.7 | 0.006 |
| NM_008606 | Matrix metallopeptidase 11 | Mmp11 | Collagen catabolism | 2.3 | 0.013 | -1.9 | 0.006 |
| NM_010929 | Notch gene homolog 4 | Notch4 | Patterning of blood vessels; cell fate determination | 2.0 | 0.005 | -2.0 | 0.006 |
| AK013448 | Protein phosphatase 1, regulatory (inhibitor) subunit 14c | Ppp1r14c | Signal transduction | -2.8 | 0.002 | 2.2 | 0.003 |
| BE137091 | Regulatory solute carrier protein, family 1, member 1 | Rsc1a1 | Regulation of protein transport and modification | 2.0 | 0.005 | -1.8 | 0.006 |
| NM_011581 | Thrombospondin 2 | Thbs2 | Inhibits microvascular endothelial cell proliferation; cell adhesion; wound repair | 2.2 | 0.002 | -1.7 | 0.004 |
FC = fold-change. Dash ("-") before number indicates down-regulation, compared to appropriate controls. NA - not applicable, where a gene without a gene symbol was identified as altered in expression (i.e., cDNA, EST, or gene encoding a hypothetical protein). ISO and Swim = Control mice versus isoproeteronol-treated or exercised mice, respectively. Gene functions were obtained from Ingenuity pathway analysis software, supplemented with information obtained from the NCBI and Stanford SOURCE search databases.