Table 5.
Genes altered under conditions of pathological cardiac hypertrophy, grouped by function
| Gene | Pathological | Phys | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| This Study | RQ | MI | AB | Sh | MI | Drug | Salt | Idiop | Isch | AS | Cong | Exercise | ||
| Mice | Rats | Humans | Rodents | |||||||||||
| FC | ||||||||||||||
| Cell adhesion and migration | ||||||||||||||
| Aoc3 | 2.2 | 1.5 | ||||||||||||
| Itgbl1 | 2.4 | 1.8 | 1.6 | 2.8 | ||||||||||
| Ltbp2 | 3.3 | 13.1 | 2 | 1.7 | 2.5 | |||||||||
| Omd | 2.6 | 5.1 | 1.9 | 2.6 | 2.4 | |||||||||
| Cardiovascular functions and/or disease association | ||||||||||||||
| Angptl2 | -2.2 | 1.7 | -1.5 | -2.3 | ||||||||||
| Atp1a1 | -1.9 | d | -4.0 | 1.8 | 2.3 | -1.7 | -1.6 | -5.3 | ||||||
| Ctgf | 3.7 | 2.1 | 3.1 | 2.7 | 1.5 | 2.2 | -3.5 | |||||||
| Dcn | 2.8 | 1.8 | 1.6 | 1.7 | 1.6 | -1.6 | ||||||||
| Fbxw7 | -1.8 | -1.5 | ||||||||||||
| Fn1 | 2.3 | 1.9 | 1.8 | 3 | 1.7 | 1.9 | 1.6 | -1.6 | -1.6 | 2 | 2 | |||
| Hif1a | -1.9 | 1.5 | -1.9 | -1.5 | ||||||||||
| Hyou1 | -1.8 | -1.9 | -1.7 | |||||||||||
| Kdr | -1.9 | 7 | -1.7 | -1.5 | 2.3 | |||||||||
| Lox | 10.1 | 24.6 | 3.5 | 1.5 | 2 | |||||||||
| Mef2c | -2.2 | -3.1 | -1.6 | |||||||||||
| MHC-β | 2.7 | 4.5 | 2.6 | 1.9 | 2.3 | 1.6* | 2.5* | |||||||
| Prox1 | -1.8 | -20 | -1.5 | -1.8 | -1.6 | |||||||||
| Sfrs2 | -2.7 | -1.7 | 3.4 | |||||||||||
| Thbs2 | 2.5 | 7 | 1.8 | |||||||||||
| Cell-cell signaling | ||||||||||||||
| Palld | -3.4 | -1.9 | 2 | |||||||||||
| Ramp1 | -3 | -1.6 | ||||||||||||
| Cellular Movement | ||||||||||||||
| Trak1 | -2 | -1.6 | ||||||||||||
| Tuba4a | -6 | -7.7 | -2.8 | -1.7 | ||||||||||
| Tubb2a | -2 | 1.6 | -1.6 | |||||||||||
| Cell cycle arrest and/or cell death | ||||||||||||||
| Ddit4 | 7 | 1.9 | -2.2 | |||||||||||
| Il17rd | 1.9 | 1.6 | ||||||||||||
| Isg20l1 | -1.6 | -1.6 | -3.6 | |||||||||||
| Prmt1 | -2.1 | -1.8 | ||||||||||||
| Scn7a | 2.1 | -2.1 | 1.9 | |||||||||||
| Development | ||||||||||||||
| Ezh1 | 1.9 | 1.8 | ||||||||||||
| Hopx | -2.5 | -18.5 | -2.5 | -3.1 | ||||||||||
| Slc40a1 | 2.1 | 1.5 | 1.6 | 2.1 | -1.7 | |||||||||
| Ttll7 | 4.2 | 1.7 | ||||||||||||
| Cell growth/proliferation | ||||||||||||||
| Brd4 | -1.8 | -1.6 | ||||||||||||
| Ccng2 | 3 | -1.7 | 1.8 | |||||||||||
| Cdh13 | -8.3 | d | -6.7 | -2 | ||||||||||
| Clu | 2.1 | 2.7 | 1.7 | 1.5 | 1.6 | 1.8 | 1.5 | -1.5 | ||||||
| Cthrc1 | 3.5 | 2.5 | 2.4 | |||||||||||
| Egr1 | -3.3 | 1.9 | -1.7 | 1.8 | 1.6 | -2.2 | 1.9 | -2.8 | ||||||
| Fkbp4 | -2.6 | -7.2 | -1.6 | -2.1 | -1.6 | -1.5 | ||||||||
| Hipk2 | -2 | 4 | -1.5 | -1.6 | -1.6 | |||||||||
| Hk2 | -2 | -6.9 | -1.8 | -1.7 | 1.5 | |||||||||
| Hsp90b1 | -8.4 | -1.6 | -1.6 | |||||||||||
| Kif1b | -3.6 | 3 | -3.6 | -1.6 | ||||||||||
| Mlf1 | -2 | -2.1 | -25.2 | -1.5 | -2 | |||||||||
| Nox4 | 4.7 | 1.6 | ||||||||||||
| Pdgfd | 1.9 | -1.6 | 2.1 | |||||||||||
| Plagl1 | 2.4 | 3.5 | 1.8 | -4.2 | ||||||||||
| Plcb4 | 1.8 | 1.6 | ||||||||||||
| Postn | 4.1 | 3.1 | 5.8 | 7.1 | 4.8 | 3.9 | 2 | 2.8 | -2.2 | |||||
| Tfrc | -12.3 | 10 | 1.8 | -1.6 | -1.7 | -1.5 | ||||||||
| Trp53inp1 | 4.3 | 1.5 | ||||||||||||
| Extracellular matrix morphology | ||||||||||||||
| Aspn | 2.6 | 1.6 | 3 | 2 | 1.8 | 2.6 | 4.5 | |||||||
| Cilp | 3.8 | 5.4 | 2.8 | 1.9 | ||||||||||
| Fbln2 | 1.7 | 1.5 | 3.2 | 2.1 | 1.6 | 1.6 | 2.2 | |||||||
| Mfap5 | 3.1 | 1.5 | 3.8 | 2.9 | 1.8 | -4.2 | ||||||||
| Other or unknown | ||||||||||||||
| Arrdc3 | 2.1 | 1.8 | ||||||||||||
| Dhrs7 | -1.6 | -1.5 | ||||||||||||
| Hs2st1 | -2 | 1.8 | -1.8 | |||||||||||
| Kcnt2 | 2.2 | -1.9 | 1.6 | |||||||||||
| Klhl24 | 2.7 | -3.1 | 1.6 | -1.6 | ||||||||||
| Obfc2a | -2.1 | -1.8 | -1.7 | |||||||||||
| Pcmtd2 | 2.1 | -1.8 | 1.6 | -3 | ||||||||||
| Reep1 | -2.8 | -3.9 | -2.5 | -1.7 | ||||||||||
| Rnase4 | 2 | 2.6 | 1.5 | 1.9 | ||||||||||
| Trmt5 | 2.4 | i | 1.5 | |||||||||||
| Tsfm | -1.7 | -3.6 | -1.5 | |||||||||||
| Zbtb44 | 2 | -1.6 | 1.6 | |||||||||||
| Zfp428 | -2.2 | 1.5 | ||||||||||||
FC = fold-change. Dash ("-") before number indicates down-regulation, compared to appropriate controls. A blank indicates that no significant alteration (fold change at least 1.5, p value ≤ 0.05) was observed. The asterisk indicates that a variant of MHC-β (MYH7B) was up-regulated. For PMAGE data, "i" and "d" indicate induction and down-regulation with 0 transcripts detected in either wild-type or αMHC403/+ mice, respectively. Idiop, Isch, AS, and Cong = idiopathic, ischemic, aortic stenosis, and congenital, respectively. "Drug" refers to angiotensin II treatment. (No gene alterations in common with ISO treatment were found for 3,5-diiodothyropropionic acid treated-rats.) Sh, MI, and AB = shunt, myocardial infarction, and aortic banding, respectively. RQ = αMHC403/+ mice, representing familial cardiac hypertrophy. Phys = physiological. Gene functions were obtained from Ingenuity pathway analysis software, supplemented with information obtained from the NCBI and Stanford SOURCE search databases. Some genes perform more than one function, but are only listed under one category.