Table 2.
Summary of putative new gene candidates implicated in the neuropathic pain model SNI at the dorsal root ganglia level.
| Affymetrix ID | Gene Name | Gene Symbol | Group | Functionality |
|---|---|---|---|---|
| 1368224_at | Serine (or cysteine) peptidase inhibitor, clade A, member 3N | SERPINA3N | IS | Inflammation [59-61] |
| 1369191_at | Interleukin 6 | IL-6 | IS | Macrophage in neuropathic pain, inflammation [35] |
| 1379631_at | Colony stimulating factor 1 (macrophage) | CSF-1 | IS | Specific factor for macrophages [73-75] |
| 1387982_at | Toll-like receptor 4 | TLR4 | IS | Inflammation/Immune response/pain [46,47] |
| 1368000_at | Complement component 3 | C3 | IS | Apoptosis, caspase activation, complement activation, pain processes [50-52] |
| 1367973_at | Macrophage chemoattractant protein-1 | MCP-1/CCL2 | IS | Chemoattractant, pain processes [41-43] |
| 1370449_at | Purinergic receptor P2Y, G-protein coupled, 14 | P2RY14 | IS | Immune response [49] |
| 1375633_at | Chloride intracellular channel 1 | CLIC-1 | IS | Cell cycle progress/Microglia activation [48] |
| 1387690_at | Caspase 3 | CASP3 | Apop | Apoptosis, inflammation, pain processes [76-78] |
| 1373623_at | Inositol 1,4,5-trisphosphate 3-kinase C | ITPKC | ST | Ca2+ homeostasis [69,79] |
| 1387809_at | Mitogen-activated protein kinase kinase 6 | MAP2K6 | ST | Modulation of p38 MAPK [62] |
| 1369737_at | cAMP responsive element modulator | CREM | RNA mod |
Crem isoform, c-fos regulation, expressed after thermal stimulation [68] |
| 1370678_s_at | Monoamine oxidase A | Maoa | NS | p38/caspase 3 apoptosis pathways [63] |
| 1368657_at | Matrix metallopeptidase 3 | MMP3 | Other | Remodellation, lymphocytes signalling, inflammation, pain processes [57,80,81] |
| 1368590_at | Matrix metalloproteinase 16 | MMP16 | Other | Matrix remodelling [54,82] |
| 1368487_at | Serine (or cysteine) proteinase inhibitor, clade B, member 2 | SERPINB2 | Other | Expressed by DRGs after injury [83] |
The table shows the identified gene by Affy_ID, name, gene symbol, Go term classification group and its putative function. IS: immune system; Apop: apoptosis; ST: signal transduction; NS: nervous system; RNA mod: RNA modulation.