Table 1.
Optimization of ethanol production.
| Modified reaction numbers | (Xi)opt/(Xi)nom | LB (NLP) | UB (MILP) | Iterations | Total time (s) |
|---|---|---|---|---|---|
| HXT | [5] | 72.68 | 72.77 | 4 | 2.05 |
| HXT, PFK | [5,2.85] | 103.66 | 103.86 | 3 | 2.64 |
| All | [5,0.9,5,0.2,5,0.2,5,5] | 157.59 | 157.70 | 4 | 0.89 |
| HXT, GLK | [5,0.75] | 72.68 | 72.77 | 4 | 1.32 |
| HXT, PFK | [5,2.85] | 103.66 | 103.86 | 3 | 0.57 |
| HXT, GAPD | [5, 5] | 73.18 | 73.31 | 4 | 1.22 |
| HXT, PYK | [5,0.63] | 72.68 | 72.77 | 4 | 1.25 |
| HXT, TPS+GOL | [5,0.2] | 73.41 | 73.54 | 4 | 1.24 |
| HXT, GLY | [5, 5] | 73.41 | 73.54 | 4 | 1.22 |
| HXT, ATPase | [5, 5] | 87.77 | 87.84 | 4 | 1.24 |
Best optimization strategies for increasing the rate of ethanol production in the model discussed as case study 1 in [27]. LB: Lower bound, UB: Upper bound. Reaction numbers refer to the mathematical model used in [27]. HXT: Glucose uptake, GLK: Hexokinase, PFK: Phosphofructokinase, GAPD: Glyceraldehide-3-phosphate dehydrogenase, PYK: Pyruvate kinase, TPS+GOL: Polysaccharide production (glycogen + tre-halose), GLY: Glycerol production.