Table 4.
Anti-P. falciparum IgG1 and IgG3 levels (median) according to IL4-590 genotypes in complicated malaria patients with or without previous malaria experiences.
| CM | ||||
|---|---|---|---|---|
| CC (5)a | CT (46)a | TT (53)a | P-value# | |
| Anti-PfIgG1* | - | 24.12 | 18.04 | 0.628 |
| 223.80 | - | 18.04 | 0.025 | |
| 223.80 | 24.12 | - | 0.037 | |
| Anti-PfIgG3* | - | 1.20 | 0.51 | 0.030 |
| 1.51 | - | 0.51 | 0.159 | |
| 1.51 | 1.20 | - | 0.455 | |
| CME | ||||
| CC (2) | CT (11) | TT (14) | P-value | |
| Anti-PfIgG1* | - | 31.13 | 53.04 | 0.983 |
| 280.43 | - | 0.835 | ||
| 280.43 | 31.13 | 53.04 | 0.830 | |
| Anti-PfIgG3* | - | 5.62 | 1.32 | 0.075 |
| 8.06 | - | 1.32 | 0.384 | |
| 8.06 | 5.62 | - | 0.961 | |
| CMN | ||||
| CC (3) | CT (33) | TT (38) | P-value | |
| Anti-PfIgG1* | - | 13.94 | 8.54 | 0.636 |
| 223.80 | - | 8.54 | 0.002 | |
| 223.80 | 13.94 | - | 0.004 | |
| Anti-PfIgG3* | - | 0.80 | 0.40 | 0.217 |
| 1.51 | - | 0.40 | 0.154 | |
| 1.51 | 0.80 | - | 0.274 | |
* = μg/ml, #Statistical analysis of differences in IgG subclass levels
between the different genotypes tested with unpaired t-test,
a = Number of patients (in the parenthesis).