Table 6.
Association between IL4-590 genotype and anti-P. falciparum -IgG1 and -IgG3 levels base on previous experiences malaria infection in patients with complicated and uncomplicated malaria.
| Complicated malaria | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Without previous malaria experiences (76)a | With previous malaria experiences (27) | |||||||||
| 3-tiles of Ig levels | CC | CT | TT | P-value# | CC | CT | TT | P-value# | ||
| Anti-PfIgG1* | Low | 0-14.47 | 0A | 17B | 21C | 0.1373 | 0 | 3 | 4 | 0.7715 |
| Medium | 14.76-106.1 | 1 | 11 | 11 | 1 | 4 | 5 | |||
| High | 107.2-1874 | 2 | 5 | 6 | 1 | 4 | 5 | |||
| Anti-PfIgG3* | Low | 0.053-0.798 | 0 | 17 | 23 | 0.2136 | 1 | 2 | 6 | 0.0156 |
| Medium | 0.854-3.55 | 2 | 10 | 11 | 0 | 2 | 7 | |||
| High | 3.629-119 | 1 | 6 | 4 | 1 | 7 | 1 | |||
| Uncomplicated malaria | ||||||||||
| Without previous malaria experiences (74) | With previous malaria experiences (91) | |||||||||
| CC | CT | TT | P-value# | CC | CT | TT | P-value# | |||
| Anti-PfIgG1 | Low | 0-14.47 | 0 | 15 | 11 | 0.8019 | 2 | 7 | 5 | 0.1219 |
| Medium | 14.76-106.1 | 2 | 9 | 12 | 1 | 11 | 20 | |||
| High | 107.2-1874 | 2 | 11 | 11 | 4 | 13 | 25 | |||
| Anti-PfIgG3 | Low | 0.053-0.798 | 1 | 13 | 12 | 0.8772 | 2 | 7 | 4 | 0.0206 |
| Medium | 0.854-3.55 | 1 | 10 | 12 | 4 | 11 | 16 | |||
| High | 3.629-119 | 2 | 12 | 11 | 1 | 14 | 30 | |||
a = Number of patients (in the parenthesis), # = Chi- squared test was used to test the difference of IL4-590 CC, CT and TT distribution between the low and high 3 tiles, * = μg/ml, A, B and C = number of patients with previous malaria experiences for determining anti-P. falciparum -IgG1, -IgG3 and carry IL4-590 CC, CT, TT genotypes, respectively.