Skip to main content
. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: J Immunol. 2009 Nov 16;183(11):7489–7496. doi: 10.4049/jimmunol.0901414

FIGURE 6.

FIGURE 6

Locostatin inhibit exacerbated TNF-α secretion. A, Mice immunized as described in legend of Fig. 1 were injected i.p. with 100 μg of locostatin or vehicle 15 min before i.p. injection with 100 μg of SIINFEKL. A summary of three independent experiments is shown. The mice were bled 1 h later; sera were tested for TNF-α presence by ELISA (pg/ml) and shown as individual scatter plots. B, In a complementary experiment, human anti-flu CTL were stimulated for 16 h with increasing doses of cognate peptide in the presence of locostatin. TNF-α and IFN-γ release was measured by ELISA. C, Human PBMC were stimulated for 3 h with increasing doses of LPS in the presence of locostatin. TNF-α and IFN-γ release was measured by ELISA.