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. 1998 Sep 1;95(18):10914–10919. doi: 10.1073/pnas.95.18.10914

Figure 5.

Figure 5

Effects of cerebral apoE expression on exploratory behavior. Active times (A), path lengths (B), as well as time (C) and frequency (D) of rearing were compared among 6-month-old female wild-type (n = 14), knockout (n = 16), NSE-apoE3 (n = 6), and NSE-apoE4 (n = 8) mice during open field activity. Bar graphs represent results (means ± SEM) obtained during the second of three 10-min observation periods. NSE-apoE4 mice showed mildly reduced active times (A), which differed significantly only from those observed in wild-type mice (P < 0.05 by Dunnett’s but insignificant by Tukey–Kramer posthoc test) and knockout mice (P < 0.05 by Tukey–Kramer posthoc test). ANOVA revealed no significant differences in pathlengths (B) among the four genotypes. Compared with wild-type controls, knockout mice and NSE-apoE4 mice showed significant reductions in frequency (C) and time (D) of rearing (P < 0.01 by Tukey-Kramer posthoc test), whereas NSE-apoE3 mice did not (Tukey–Kramer or Dunnett’s posthoc tests).