Table 1. The 11 ER QTL with most strongly confirmed predictions.
Gene symbol | % within-strain variance explained by ER QTL | QTL chr | QTL pos | Predicted more variable strain | B6∶A/J log2 variance ratio |
Hsd3b5 | 58.3 | 15 | 46057296 | B6 | 7.6 |
T | 62.7 | 9 | 43663988 | B6 | 4.3 |
BE655403 | 57.8 | 6 | 80679828 | B6 | 3.0 |
Olfr125 | 84.2 | 1 | 1.72E+08 | B6 | 3.1 |
1110065F06Rik | 56.5 | 11 | 63036066 | B6 | 3.2 |
Spon2 | 63.6 | 2 | 77180992 | B6 | 2.5 |
Chrna4 | 59.5 | 5 | 8411367 | B6 | 3.2 |
Slc25a25 | 69.3 | 6 | 53955400 | A/J | −2.7 |
Aacs | 78.4 | 1 | 27827338 | A/J | −2.9 |
Il23r | 53.9 | 6 | 6583041 | A/J | −3.1 |
Sdf2l1 | 54.3 | 1 | 1.84E+08 | A/J | −2.6 |
Genes with ER QTL from the 19-strain set whose genotypes differed between A/J and B6 strains were tested in an independent group of A/J and B6 female livers (see Materials and Methods). The 11 genes with the strongest confirmation (measured by magnitude of the B6∶A/J variance ratio in the replication data set) are shown.