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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Hepatology. 2010 Jan;51(1):121–129. doi: 10.1002/hep.23276

Table 4.

Baseline Characteristics and Change (mean [SD]) in Histologic parameters according to study goal weight reduction (≥ 7%)

Variable Wt Loss < 7%
(n=17)
Wt Loss ≥ 7%
(n=11)
P-values
Baseline Characteristics
BMI Category, N
(%)
-overweight (25-
29.9 kg/m2)
-obesity class I (30-
34.9 kg/m2)
-obesity class II (35-
40 kg/m2)


5 (26.3)

5 (26.3)

9 (47.4)


3 (27.3)

6 (54.5)

2 (18.2)


0.21
Diabetes, N (%) 10 (52.6) 4 (36.4) 0.39
On metformin, N
(%)
7 (36.8) 2 (18.2) 0.28
Histologic Parameters
Fat
(0-3)
−0.41 (0.80) −1.36 (0.67) <0.001
Lobular
inflammation
(0-3)
−0.24 (0.75) −0.82 (0.75) 0.03
Ballooning Injury
(0-2)
−0.53 (0.80) −1.27 (0.47) 0.03
Fibrosis
(0-4)
+ 0.06 (0.83) −0.45 (0.93) 0.10
NAS
(0-8)
−1.18 (1.59) −3.45 (1.21) <0.001
Participants with ≥3
points improvement
in NAS from
baseline, N (%)
4 (23.5) 9 (81.8) 0.003
Participants with
NAS ≤2 at follow
up, N (%)
4 (23.5) 10 (90.9) <0.001