TABLE 2.
Risk factors for death in all HIV-infected participants†
| Unadjusted (n=922*) |
Adjusted (n = 922*) |
|||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Demographic Factors | ||||||
| Female vs. Male | 1.13 | (0.77, 1.66) | 0.53 | 1.23 | (0.79, 1.91) | 0.36 |
| African-American vs. Caucasian | 1.72 | (1.17, 2.52) | 0.006 | 1.27 | (0.81, 1.97) | 0.30 |
| Other vs. Caucasian | 1.47 | (0.81, 2.68) | 0.21 | 1.80 | (0.95, 3.43) | 0.074 |
| Age (per decade) | 1.25 | (1.03, 1.52) | 0.024 | 1.61 | (1.27, 2.05) | <.0001 |
| HIV-related Factors | ||||||
| Current CD4 (log2) | 0.63 | (0.58, 0.69) | <.0001 | 0.65 | (0.58, 0.73) | <.0001 |
| Detectable HIV RNA | 1.92 | (1.32, 2.78) | 0.001 | 0.88 | (0.56, 1.37) | 0.56 |
| AIDS (by CD4 or OI/OM) | 3.00 | (1.75, 5.16) | <.0001 | 1.66 | (0.90, 3.08) | 0.11 |
| HCV infection | 2.04 | (1.40, 2.97) | 0.0002 | 1.16 | (0.74, 1.83) | 0.52 |
| Traditional Risk Factors | ||||||
| Smoking: current vs. never | 2.81 | (1.77, 4.46) | <.0001 | 2.73 | (1.64, 4.53) | 0.0001 |
| Smoking: past vs. never | 1.40 | (0.79, 2.49) | 0.24 | 1.46 | (0.81, 2.64) | 0.21 |
| Diabetic | 0.93 | (0.49, 1.78) | 0.83 | 1.01 | (0.50, 2.03) | 0.99 |
| Systolic BP (per 10 mmHg) | 0.93 | (0.82, 1.05) | 0.25 | 0.93 | (0.76, 1.13) | 0.45 |
| Diastolic BP (per 10 mmHg) | 0.98 | (0.83, 1.16) | 0.82 | 1.15 | (0.88, 1.52) | 0.31 |
| Non HDL Cholesterol (per 10 mg/dL) | 0.92 | (0.88, 0.95) | <.0001 | 0.96 | (0.92, 1.00) | 0.050 |
| HDL Cholesterol (per 10 mg/dL) | 0.91 | (0.81, 1.03) | 0.13 | 0.88 | (0.78, 1.01) | 0.063 |
HR, hazard ratio; CI, confidence interval; BP, blood pressure; OI, opportunistic infection; OM, opportunistic malignancy;
†
Observed case exponential regression mortality analysis
*
N includes all HIV-infected participants known to be dead (N=128) or alive (N=794) and excludes those who were lost to follow-up