Table 1.
A Partial list of overlapped glycoproteins between human CSF and brain tissue
| Protein IPI | Description | Comments (source: UniPortKB/Swiss-Prot database) |
|---|---|---|
| IPI00002714.1 | Dickkopf-related protein 3 precursor | Inhibitor of Wnt signaling pathway (Potential). Highest expression in heart, brain, and spinal cord |
| IPI00003813.5 | Isoform 1 of cell adhesion molecule 1 precursor | May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. |
| IPI00009997.1 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase | Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans. In the adult, highly expressed in heart, brain, skeletal muscle and kidney |
| IPI00011732.2 | Isoform 1 of GDNF family receptor alpha-2 precursor | Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Isoform 1 is found in brain and placenta |
| IPI00013303.2 | Limbic system-associated membrane protein precursor | Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hippocampal mossy fiber projection (By similarity) |
| IPI00017601.1 | Ceruloplasmin precursor | Defects in CP are the cause of aceruloplasminemia. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain/visceral organs. |
| IPI00020557.1 | Prolow-density lipoprotein receptor-related protein 1 precursor | May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission |
| IPI00024035.1 | Isoform 1 of cadherin-6 precursor | Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. |
| IPI00024966.1 | Contactin-2 precursor | Attached to the neuronal membrane by a GPI-anchor and is also released from neurons. May play a role in the initial growth and guidance of axons. May be involved in cell adhesion |
| IPI00026946.2 | Neuronal pentraxin-2 precursor | Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner |
| IPI00030887.1 | Tyrosine-protein kinase Receptor TYRO3 precursor | May be involved in cell adhesion processes, particularly in the central nervous system |
| IPI00031121.2 | Carboxypeptidase E precursor | Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin. Neuropeptide signaling pathway |
| IPI00064667.4 | Beta-Ala-His dipeptidase p recursor | Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine. |
| IPI00159927.2 | Neurocan core protein precursor | May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid |
| IPI00160552.3 | Isoform 1 of tenascin-R precursor | Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components |
| IPI00171473.2 | Spondin-1 precursor | Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell |
| IPI00176427.1 | Cell adhesion molecule 4 precursor | Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor- suppressor activity. |
| IPI00216641.1 | Isoform 2 of contactin-1 precursor | Contactins mediate cell surface interactions during nervous system development. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth |
| IPI00217882.3 | Sortilin precursor | Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. |
| IPI00295832.1 | Oligodendrocyte-myelin glycoprotein precursor | Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system. |
| IPI00301512.3 | Isoform DPPX-L of Dipeptidyl aminopeptidase-like protein 6 | May be involved in the physiological processes of brain function. Has no dipeptidyl aminopeptidase activity. May modulate the cell surface expression and the activity of the potassium channel KCND2. |
| IPI00303210.3 | Isoform 2 of ectonucleotide pyrophosphatase/phosphodiest erase family member 2 precursor | Involved in several motility- related processes such as angiogenesis and neurite outgrowth |
| IPI00332887.5 | signal-regulatory protein alpha precursor | Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. |
| IPI00376427.3 | Neural cell adhesion molecule 2 precursor | May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons |
| IPI00413696.5 | 41 kDa protein | Plays an important role in memory formation and synaptic plasticity in the hippocampus |
| IPI00456623.2 | Isoform 1 of brevican core protein precursor | May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. |
| IPI00470696.1 | Isoform 1 of netrin receptor UNC5D precursor | Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. |
| IPI00479514.1 | Voltage-dependent calcium channel subunit alpha-2/delta-1 precursor | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling |
| IPI00513964.1 | Isoform 2 of semaphorin-4B precursor | Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons |
| IPI00552450.1 | Opioid binding protein/cell adhesion molecule-like isoform b preproprotein | Binds opioids in the presence of acidic lipids; probably involved in cell contact |
| IPI00554760.1 | Isoform 2 of tenascin-R precursor | Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth |
| IPI00655702.3 | Isoform 5 of neurofascin precursor | Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions |
| IPI00783390.1 | Isoform 1 of neural cell adhesion molecule L1-like protein precursor | Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. |
| IPI00797025.1 | Major prion protein | PrP is found in high quantity in the brain of humans and animals infected with neurodegenerative diseases known as transmissible spongiform encephalopathies or prion diseases, like: Creutzfeldt-Jakob disease |
| IPI00807403.1 | Isoform 2 of CD166 antigen precursor | Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system. |
| IPI00855821.1 | Isoform 2 of neurexin-1-alpha precursor | Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. |
| IPI00873446.1 | Isoform 5 of neuronal cell adhesion molecule precursor | Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier |