Table II.
Composition of Various Formula of Ondansetron with Different Release Enhancers
| Ingredients (mg) | Formula composition | |||||||
|---|---|---|---|---|---|---|---|---|
| S1 | S2 | S3 | S4 | S5 | S6 | S7 | S8 | |
| OH | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| (CP 934) 15% | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 |
| SCMC LV | 165 | 165 | 165 | 165 | 165 | 165 | 165 | 165 |
| PEG 6000 | 10 | 20 | 30 | 40 | 40 | 40 | 40 | 40 |
| Lactose | – | – | – | – | 5 | 10 | 15 | 20 |
| Magnesium stearate | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 |
| Aspartame | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
OH ondansetron hydrochloride, CP 934 carbopol-934, SCMC LV sodium carboxymethyl cellulose low viscosity, PEG 6000 polyethyleneglycol 6000