Table VI.

Comparison of the Three Ondansetron Forms of Optimized Formulae

Parameters	Formulae of ondansetron hydrochloride	Formulae of complexed ondansetron	Formulae of based ondansetron
Hardness	7.0 ± 0.15	7.50 ± 0.18	7.30 ± 0.25
% drug content	99.45 ± 0.5	100.52 ± 0.4	100.23 ± 0.6
% loss in weight	0.065 ± 0.005	0.070 ± 0.003	0.066 ± 0.008
Surface pH	6.95 ± 0.08	6.88 ± 0.07	6.00 ± 0.05
% swelling index (8 h)	68.50 ± 0.80	70.55 ± 0.50	64.50 ± 0.80
Bioadhesive strength (g)	134.05 ± 2.50	132.05 ± 1.80	130.05 ± 2.50
In vitro drug release (8 h)	88.148 ± 3.65	96.83 ± 2.88	62.95 ± 2.23
In vitro buccal permeation (8 h)	62.96 ± 1.52	73.96 ± 1.73	43.46 ± .88