Table II.
Physicochemical Characteristics of Different Chitosan Microspheres
| Serial number | Formulation code | Preparation medium | Size (µm) | PDI | Zeta potential (mv) | Percentage entrapment efficiency | Percent mucoadhesivity | Characteristics | Percent process yield |
|---|---|---|---|---|---|---|---|---|---|
| 1 | MC | Castor oil | 11.52 ± 0.57 | 1.01 ± 0.046 | 1.13 ± 0.04 | 43.12 ± 2.14 | 58 | Heavily clumped | 47 |
| 2 | MH | Heavy liquid paraffin | 9.62 ± 0.43 | 0.88 ± 0.035 | 2.47 ± 0.08 | 52.61 ± 1.35 | 66 | Large aggregates | 53 |
| 3 | ML | Light liquid paraffin | 5.62 ± 0.14 | 0.41 ± 0.012 | 2.86 ± 0.05 | 65.32 ± 1.21 | 72 | Loosely aggregated and redispersible | 70 |
| 4 | MPL | 1:1 mixture of petroleum ether and light liquid paraffin | 3.15 ± 0.04 | 0.20 ± 0.02 | 3.05 ± 0.04 | 68.87 ± 1.03 | 75 | Free flowing | 73 |
Values shown are mean ± SD, where n = 3
PDI polydispersion index