Table I.
Composition of Factorial Design Batches
| Batch code | Variables levels in coded | %DE60 ± SDa | %Yield ± SD | |
|---|---|---|---|---|
| X 1 | X 2 | |||
| C1 | −1 | −1 | 32.83 ± 0.61 | 69.7 ± 0.80 |
| C2 | −1 | 0 | 34.75 ± 0.43 | 72.1 ± 1.05 |
| C3 | −1 | +1 | 36.98 ± 0.50 | 75.8 ± 1.21 |
| C4 | 0 | −1 | 39.63 ± 0.27 | 92.4 ± 0.85 |
| C5 | 0 | 0 | 40.98 ± 0.83 | 91.3 ± 1.05 |
| C6 | 0 | +1 | 42.41 ± 0.29 | 93.6 ± 0.75 |
| C7 | +1 | −1 | 42.91 ± 0.74 | 80.4 ± 0.60 |
| C8 | +1 | 0 | 44.00 ± 0.63 | 85.0 ± 0.40 |
| C9 | +1 | +1 | 44.86 ± 0.44 | 89.0 ± 0.29 |
| Actual values | ||||
| Coded terms | ||||
| −1 | 1:2 | 10 | ||
| 0 | 1:5 | 20 | ||
| +1 | 1:8 | 30 | ||
X 1 drug to polymer ratio, X 2 kneading time, %DE 60 dissolution efficiency at 60 min
aValues represent the mean ±SD of three experiments