Table I.
Solubility of OA and UA in Different Solvent Systems
| [C] (%, v/v) | [L] (mmol/L) | [D t] (mmol/L) | |
|---|---|---|---|
| OA | UA | ||
| 0 | 5 | 0.0880 | 0.0178 |
| 0 | 10 | 0.2099 | 0.0336 |
| 0 | 20 | 0.5120 | 0.0863 |
| 0 | 40 | 1.2645 | 0.2026 |
| 0 | 60 | 2.1518 | 0.3845 |
| 0.5 | 5 | 0.0840 | – |
| 0.5 | 10 | 0.2101 | 0.0113 |
| 0.5 | 20 | 0.5200 | 0.0596 |
| 0.5 | 40 | 1.2942 | 0.1990 |
| 0.5 | 60 | 2.3051 | 0.3801 |
| 5 | 5 | 0.0178 | – |
| 5 | 10 | 0.0437 | – |
| 5 | 20 | 0.1416 | 0.0192 |
| 5 | 40 | 0.6146 | 0.0512 |
| 5 | 60 | 1.0351 | 0.0760 |
| 10 | 5 | 0.0122 | – |
| 10 | 10 | 0.0284 | – |
| 10 | 20 | 0.0841 | – |
| 10 | 40 | 0.2760 | 0.0183 |
| 10 | 60 | 0.4400 | 0.0368 |
| 20 | 5 | 0.0152 | – |
| 20 | 10 | 0.0362 | – |
| 20 | 20 | 0.0882 | – |
| 20 | 40 | 0.2499 | 0.0172 |
| 20 | 60 | 0.4076 | 0.0315 |
| 40 | 0 | 0.0310 | 0.0085 |
| 40 | 5 | 0.0847 | 0.0151 |
| 40 | 10 | 0.1278 | 0.0162 |
| 40 | 20 | 0.2243 | 0.0211 |
| 40 | 40 | 0.4265 | 0.0319 |
| 40 | 60 | 0.7526 | 0.0477 |
| 60 | 0 | 0.4548 | 0.3051 |
| 60 | 5 | 0.4935 | 0.3532 |
| 60 | 10 | 0.5307 | 0.3561 |
| 60 | 20 | 0.6235 | 0.3979 |
| 60 | 40 | 0.8922 | 0.4754 |
| 60 | 60 | 1.1267 | 0.5686 |
| 80 | 0 | 3.4537 | 2.4564 |
| 80 | 5 | 3.6232 | 2.9685 |
| 80 | 10 | 3.8212 | 3.0515 |
| 80 | 20 | 4.1001 | 3.3876 |
| 80 | 40 | 4.9727 | 3.7864 |
| 80 | 60 | 5.7494 | 4.1173 |
[C] concentration of ethanol, [L] concentration of HP-β-CD, [D t] total drug in the solution, – represents [D t] < 1 μg/mL