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Release of diltiazem from alginate matrix tablets in a acidic medium (pH 1.2) and b in acidic medium for 2 h followed by in PB solution (pH 6.8). SAL/CG ratio: open circles 3:1 (F1), open triangles 2:1 (F2), open squares 1:1 (F3), filled circles 1:1.5 (F4), filled triangles 1:2 (F5), filled squares 1:3 (F6). Each data point is the mean of four determinations (maximum SEM ±1.9%)
